Effect of defects on thermal denaturation of DNA oligomers

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چکیده

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Effect of defects on thermal denaturation of DNA oligomers.

Effect of defects on the melting profile of short heterogeneous DNA chains is calculated using the Peyrard-Bishop Hamiltonian. On-site potential on a defect site is represented by a potential that has only a short-range repulsion and a flat part without well of the Morse potential. Stacking energy between two neigbouring pairs involving a defect site is also modified. The results are found to b...

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Thermal denaturation of A-DNA

The DNA molecule can take various conformational forms. Investigations focus mainly on the so-called ‘B-form’, schematically drawn in the famous paper by Watson and Crick [1]. This is the usual form of DNA in a biological environment and is the only form that is stable in an aqueous environment. Other forms, however, can teach us much about DNA. They have the same nucleotide base pairs for ‘bui...

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ژورنال

عنوان ژورنال: Physical Review E

سال: 2001

ISSN: 1063-651X,1095-3787

DOI: 10.1103/physreve.64.042901